Target

• FunctionAssociates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
• Tissue specificitySecreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells （at protein level）.
• Sequence similaritiesBelongs to the IL-6 superfamily.
• Developmental stageExpressed by newborns dendritic cells.
• Cellular localizationSecreted. Secreted upon association with IL12B.

Target information above from: UniProt accession Q9NPF7 The UniProt Consortium
The Universal Protein Resource （UniProt） in 2010
Nucleic Acids Res. 38:D142-D148 （2010）.

Information by UniProt
• Database links
  • Entrez Gene: 51561 Human
  • Entrez Gene: 83430 Mouse
  • Entrez Gene: 83430 Mouse
  • Omim: 605580 Human
  • SwissProt: Q9NPF7 Human
  • SwissProt: Q9EQ14 Mouse
  • SwissProt: Q9EQ14 Mouse
  • Unigene: 98309 Human

  • Unigene: 382212 Human
  • Unigene: 98309 Human
  • Unigene: 125482 Mouse
  • Unigene: 125482 Mouse

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• Alternative names
  IL 23 antibodyIL 23A antibodyIL-23 subunit alpha antibody

  IL-23-A antibodyIL-23p19 antibodyIL23 antibodyIl23a antibodyIL23A_HUMAN antibodyIL23P19 antibodyInterleukin 23 alpha subunit p19 antibodyInterleukin 23 p19 subunit antibodyInterleukin-23 subunit alpha antibodyInterleukin-23 subunit p19 antibodyJKA3 induced upon T cell activation antibodyMGC79388 antibodyP19 antibodySGRF antibody

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